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Thyroid

What is thyroid cancer?

Anyone can develop thyroid cancer, regardless of age or gender. The incidence rates are very low and the cure rate is very good. Some of the risk factors include:

  • Family history - a susceptibility to thyroid cancer can be inherited.
  • Gender - more women than men develop thyroid cancer.       
  •  Radiation exposure - high doses of radiation were used during the 1950s  to treat disorders of the throat and skin.

Types of thyroid cancer    

  •  Papillary- the commonest by far. Often involves adjacent lymph nodes but this has little bearing on the prognosis       
  •  Follicular- about 10% of cancers. Most are low-grade or minimally invasive       
  •  Medullary- about 5% of cancers. Other family members may be affected and it can be associated with other endocrine abnormalities.       
  •  Anaplastic- a very rare rapidly growing and aggressive cancer.       
  •  Lymphoma- also very rare but very treatable with radiotherapy and chemotherapy    
  • Secondary spread of another cancer e.g. breast or kidney cancer

 

Presentation of thyroid cancer  

Usually presents as a nodule in the thyroid. This can be the only nodule, a solitary nodule, or part of a multinodular goitre. Most are slow growing and are noticed one day when looking in the mirror, feeling one’s    neck or are pointed out by a friend.

They may have already involved nodes in the neck at presentation but this by itself is not a worrying feature.

The cancer can occasionally invade adjacent structures such as a nerve to the voice-box causing hoarseness, or it can involve the wind-pipe or  the oesophagus.

Treatment of thyroid cancer      

Nearly all thyroid cancers can be treated surgically even those that are  involving adjacent structures with minimal long-term morbidity. After surgery for papillary and follicular cancer, residual thyroid cells can  be destroyed by a drink of radioiodine (see below), and the patient is given thyroid tablets for life to replace the thyroid gland and to suppress  recurrence of thyroid cancer.

 

A thyroidectomy is the removal of all (total thyroidectomy) or part of the thyroid gland (usually half or a hemi-throidectomy). You may need to have this done because you have a swelling or enlarged gland, or for thyroid cancer treatment.

Dr McIvor will explain to you whether a part or all of your thyroid needs  to be removed, in order for you to give fully informed consent. If you do not understand any of the information please ask.

The thyroid gland gets its name from the Greek word “thureus” which means “shield” because it is composed of two lobes or sides each with the shape of a shield .  The thyroid  manufactures hormones from dietary iodine and releases them into the blood-stream. The thyroid hormones  are thyroxine and tertroxin.

Thyroid hormones cause cells to increase their metabolic rate and are important for growth, including hair, skin, bones, for repair of damaged tissues, for nerve and muscle function. They help regulate energy expenditure. They can be considered to be like a health tonic. We need a certain amount to feel well but too much can lead to a racing heart, weight loss, tremor etc.

 Size and location

We each have one thyroid gland composed of two sides or lobes which lie on either side of the trachea or wind-pipe and which are joined by a strip of thyroid tissue called the isthmus. The entire gland weighs about 15g and in its normal state is soft, not visible and can’t be felt.


 Regulation of the thyroid gland

The pituitary gland prompts the thyroid to make its hormones by releasing thyroid-stimulating hormone (TSH). There is a feed-back mechanism whereby the pituitary releases TSH into the blood, stimulating the thyroid gland to release it’s hormones. The levels of thyroid hormone in the blood increase until at a certain level the pituitary is inhibited, TSH secretion diminishes and the thyroid hormone level is stabilized. In this way the level of thyroid hormones in the blood stream are kept within a normal range.

What are typical thyroid investigations?

  • physical examination – to determine the size of the thyroid and whether nodules and are present. The detect enlarged lymph nodes. Often to exam the voice box to check vocal cord function as these are        supplied by nerves that rum next to the thyroid.
  • blood tests - to check for thyroid hormone levels and particular antibodies. Most goitres even those with cancers have normal hormone levels as most of the gland has normal cells which produce the correct amount. An overactive nodule is highly unlikely to be malignant.
  • ultrasound scan – to determine the characteristics of the gland and any nodules and to look at the adjacent neck nodes. Dr McIvor does this in his clinic.
  • fine needle biopsy of a nodule– this is done under local anaesthetic in the clinic. Often ultrasound is used to direct the needle to a specific area of the nodule. The test is occasionally a little uncomfortable but        usually not. Cells are aspirated and smeared on a slide. Results take about a week and can be a useful guide as to the nature of the nodule

Thyroid nodules are lumps that grow on the gland. Around 20 per cent of solitary nodules are cancerous (see below). Where there are multiple nodules causing thyroid enlargement, the gland is called a multinodular goitre. The incidence of a thyroid cancer in a multinodular goitre is around 4% of which the majority are low grade cancers.

What is a goitre?

A goitre is simply an enlarged thyroid gland. It is a descriptive term and doesn’t tell us why the gland is enlarged. A goitre can be due to:

  •  Insufficient iodine in the diet 
  •  High consumption of certain foods that neutralise iodine, such as cabbage, broccoli and cauliflower. Other foods, like soy, may also induce goitres      
  • Certain drugs, such as lithium and phenylbutazone
  •  Nodules growing within the thyroid gland      
  • Hyperthyroidism (overactive thyroid)      
  •  Hypothyroidism (underactive thyroid)       
  •  Thyroid cancer

Iodine Deficiency      

As the thyroid needs iodine to make its hormones, low dietary iodine intake leads to diminished thyroid hormone manufacture and release. The pituitary keeps sending chemical messages to the thyroid

 (elevated TSH levels) thus causing thyroid enlargement.

In New Zealand for some time there has been iodine added to salt to ensure  that we all get enough for thyroid hormone production. However, in recent years the population has reduced its salt intake because of other health concerns such as hypertension and fluid retention. As a result, it is possible that some are no longer getting an adequate supply of iodine.

Nodules      

 In New Zealand the commonest cause of goitre is the presence of multiple nodules within the gland producing a multinodular goitre. The cause for this seems to be a hormonal imbalance within the gland itself. Some cells are more active than others, multiplying faster to produce thickenings that become lumps or nodules. Occasionally one nodule may grow faster than other thyroid nodules and will usually be investigated to rule out a cancer.

What is hyperthyroidism or Graves’ disease?

Hyperthyroidism means the thyroid gland is overactive. A common cause is Graves' disease named after a Dr Grave who first described it. In this condition the immune system produces antibodies that act like TSH to        stimulate the thyroid gland uncontrollably produce an excessive amount of hormone and thyroid enlargement. Some of the symptoms of hyperthyroidism include a racing and irregular heart, restlessness, unexplained weight loss, heat intolerance and diarrhoea.

What is hypothyroidism?

Hypothyroidism means the thyroid gland is underactive. In this situation the pituitary gland keeps sending its chemical messages (TSH), instructing the thyroid to produce its hormones. The thyroid gland enlarges as it attempts to comply. Apart from iodine deficiency, other causes of hypothyroidism include Hashimoto's disease (which, like Graves' disease, is an autoimmune disease), treatment for hyperthyroidism, and dysfunction of the pituitary gland. Some of the symptoms of hypothyroidism include low energy, depression, cold intolerance and constipation.

When and where will the operation be done?

What must I do in the week(s) before surgery? ( Insurance, Hospital, Family, Work)

What do I need to bring the day of Surgery?

What preparation will I need for the operation?

Your operation will be carried out under a general anaesthetic which means that you will be fully unconscious for the whole operation. Removing all or part of the thyroid involves delicate surgery which means that the operation can take about two hours.
To prevent vomiting and other complications during your operation, it is necessary that you should not eat anything for at least six hours prior to your operation. You will be advised from what time you should starve by letter from Dr McIvor’s secretary.
You should expect to be in hospital for one to two days, or longer if any complications arise.

What will happen when I go into Theatre?

What will happen when I get back on the ward following Surgery?

Is it a safe operation and what are the side effects?

  • Removal of half the thyroid gland (hemi-thyroidectomy) usually leaves you sufficient thyroid tissue for your thyroid hormone requirements.  Unless the other side has already been removed or is underactive, it is very unusual to require thyroid tablets. 
  • The total removal of the thyroid gland means that you will need to take replacement hormone tablets called thyroxine every day for the rest of your life, otherwise you will experience symptoms of hypothyroidism (underactive thyroid).
  • Thyroxine tablets are the size of a sugar sweetener and safe to take. With monitoring by your general practitioner (GP), you should be able to lead an active and normal life.
  •  If you have a thyroid cancer, Thyroxine tablets are also given to suppress the level of thyroid stimulating hormone (TSH) so that residual thyroid cells are not stimulated to grow. So most thyroid cancer patients will be given thyroxine even if they have only had part of the thyroid removed.
  • If you are put on Thyroxine you will need regular blood tests to measure the levels of hormones in your blood, and your medication will be adjusted accordingly. Initially these tests might be every 6 weeks or so but once stable an annual check is usually sufficient.
  • Thyroidectomy does not affect your ability to have children, but do ask for advice and information first if you are thinking of starting a family.
  • With thyroid surgery it is sometimes necessary to remove one or more of the parathyroid glands, and then the blood calcium level may fall below normal. If or when this happens you will be advised to take additional calcium and sometimes vitamin D as well. Usually this is only for a few weeks, but in 1-2% of cases it is permanent.

    Will it affect my voice?

    The thyroid gland lies close to the voice box (larynx) and the nerves to the voice box. Following your surgery you may find that your voice sounds hoarse and weak and your singing voice may be slightly altered, but this generally recovers quite quickly. In a very small number of cases this voice change may be permanent.

    The main nerve that goes to the larynx is the recurrent laryngeal nerve.  Dr McIvor’s incidence of temporary injury to this nerve is around 1% and the rate of permanent injury is less than that.  Occasionally the nerve is involved by cancer and requires removal which causes a weak and breathy voice.  Dr McIvor is also a specialist in voice surgery and he can do a small operation under local anesthetic with sedation that will return the voice to close to normal.

    Will my calcium levels be affected following thyroid surgery?
    The parathyroid glands are situated close to the thyroid and control the level of calcium in the blood. There are usually 2 glands on each side and only one is needed to have normal calcium levels.
    Following hemi-thyroidectomy, providing the other side has never been operated on, calcium problems are extremely unlikely as there will be normal glands on the un-operated side.
    Sometimes after total thyroidectomy all the parathyroid glands are affected and you may experience tingling sensations in the hands, fingers, in your lips or around the nose. Sometimes people may feel quite unwell. Blood tests will be taken to monitor the levels of calcium in your blood immediately following surgery and again the next day.
    After total thyroid removal if the level of calcium is falling, this can easily be treated by calcium supplementse given via an intravenous drip and/or by tablets. Around 10% of patients need to take these tablets temporarily for a few weeks until the parathyroids recover. Only 1-2% of patients require permanent calcium supplementation.
    If you are placed on calcium supplements, you may need to have blood tests to check calcium twice a week for a few weeks. Dr McIvor will advise you on this.

    Will my calcium levels be affected following thyroid surgery?

    The parathyroid glands are situated close to the thyroid and control the level of calcium in the blood. There are usually 2 glands on each side and only one is needed to have normal calcium levels.

    Following hemi-thyroidectomy, providing the other side has never been operated on, calcium problems are extremely unlikely as there will be normal glands on the un-operated side.

    Sometimes after total thyroidectomy all the parathyroid glands are affected and you may experience tingling sensations in the hands, fingers, in your lips or around the nose. Sometimes people may feel quite unwell. Blood tests will be taken to monitor the levels of calcium in your blood immediately following surgery and again the next day.

    After total thyroid removal if the level of calcium is falling, this can easily be treated by calcium supplementse given via an intravenous drip and/or by tablets.  Around 10% of patients need to take these tablets temporarily for a few weeks until the parathyroids recover.   Only 1-2% of patients require permanent calcium supplementation. 

    If you are placed on calcium supplements, you may need to have blood tests to check calcium twice a week for a few weeks.  Dr McIvor will advise you on this.

    Will I have neck stiffness, restricted shoulder movement or pain?

    You will feel some discomfort and stiffness around your neck but you will  be given some medication to help ease this. Pain relief may be given in different ways, such as injections, liquid medicine or tablets. Most patients say the discomfort is not as bad as they expected, and after the first day are up and walking around.  You will also be given some gentle neck exercises to do.

    Following discharge on the first or second day Dr McIvor prescribes paracetamol and an anti-inflammatory for 5 days which suffices for any discomfort.  After a few weeks you should be back to a good standard of neck movement and shoulder function. 

    Will I have a scar?

    Following surgery, whether all or part of your thyroid is removed, you will have a scar, but once this is healed it is usually not very noticeable. The scar runs in the same direction as the natural lines of the skin on your neck. The pressure of rubbing the cream in will also help to soften the scar. If your neck becomes increasingly painful, red or swollen or you notice any discharge then please seek medical advice from Dr McIvor or your GP

    What are the costs for thyroidectomy?

    There are generally 3 costs for any procedure:  surgeon’s fee, anesthetist’s fee, hospital fee. These are given separately by the surgeon, the anaesthetist and the hospital and are to be paid separately. 

     Dr McIvor’s secretary will give or post to you an estimate for all three of these costs.  It is important that you discuss this with your insurance company prior to coming into hospital. 

    The hospital account is to be paid at the time of discharge from the hospital. The anaesthetic and surgeon fees should be settled on receipt of the account through the post or at the post-operative appointment.

    How will I feel after the operation?

    Surprisingly good is the answer.  I have had thyroid surgery so I  know.  My anaesthetist Graeme Crookes also put me to sleep for my thyroid operation. He is excellent. Once you are asleep, Graeme puts lots of local anesthetic into the neck around the operation site to reduce  pain during the procedure. That way he doesn’t have to give heavy pain-killers and as a result you have a lighter anesthetic and wake up faster. 

    You can eat and drink and receive visitors on the evening of surgery. If there is a drain it is usually kept in overnight. There may be a sensation of mucus in the throat that causes you to “ahem” a bit over the first week. Paracetamol and maybe an anti-inflammatory for a few days is all the pain relief required. 

    Despite all this you should plan a week and preferably 10 days off work as anesthetics tend to make you a bit tired.

    What care do I need to take regarding my neck wound?

    Keep your neck wound clean and dry. There will be a paper tape over the wound to protect the wound.

    After your skin tapes are removed at your one week appointment and the scar is healing well you can rub a small amount of unscented moisturising cream on the scar so it is less dry as it heals.  Vitamin A, Vitamin E, Bio-oil , or Aloe Vera are effective. Take care not to knock your wound and remember to keep the wound dry if it becomes wet after bathing or showering by patting it dry with a clean towel.

    What rest do I need and when should I return to work?

    You will need to take it easy while your neck wound is healing. This means avoiding strenuous activity and heavy lifting for a couple of weeks. The      wound area will gradually feel less stiff and you will soon be able to enjoy your normal activities.

    You will probably need to take one to two weeks off work (or sometimes longer) depending on your occupation and the nature of your work. Dr McIvor can issue you with a note for two weeks and then you should see your GP if more time is required.

    What about my medications and tablets?

    Please continue to take the medication you have been prescribed and ensure that you have a good supply. If you are unsure about any of the tablets you need to take, please check this with a nurse before you go home. Repeat prescriptions can be obtained from your GP.

    What follow-up will there be?

    Following your discharge you will need to be reviewed in the outpatient clinic to check how your wound is settling down, your hormone levels and how you are feeling. You will usually receive the date and time for this appointment through the post or by phone from Dr McIvor’s secretary. Please contact Dr McIvor’s secretary 09 4887349 if you do not receive one shortly following discharge.

    Depending on the problem with your thyroid and the results from the thyroid tissue that has been removed, you may be offered further treatment. Dr McIvor will be discuss this with you at your clinic appointment.  

    • In the event of a hemithyroidectomy for benign disease, a blood test will be arranged for one month to check that the remaining thyroid tissue is producing enough thyroid hormone for your requirementys.
    • Following total thyroidectomy, a blood test will be arranged for one month to check that the dose of thyroxine is sufficient.  This will be re-checked in a further 6 weeks or so and then at regular intervals.  Ultimately once the thyroxine dose is stabilized an annual check will suffice. 
    • If you are on calcium supplements blood tests for calcium will be initially        twice a week.

     If you have had thyroid surgery for cancer then you may need further        treatment (e.g. radioiodine therapy) and an appointment will be arranged        for you with an endocrinologist  to discuss this further.  Surveillance        will be lifelong with most patients ending up with an annual check-up.